Brohall G, Schmidt C, Behre C J, Hulthe J, Wikstrand J, Fagerberg B
Wallenberg Laboratory for Cardiovascular Research, Academy at Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden.
Nutr Metab Cardiovasc Dis. 2009 Jun;19(5):327-33. doi: 10.1016/j.numecd.2008.02.002. Epub 2008 Dec 20.
Impaired glucose tolerance (IGT) is regarded as a transient metabolic state leading to type-2 diabetes, and is known to predict future risk of cardiovascular disease. This study was designed to investigate if IGT is associated with subclinical atherosclerosis.
In a population-based cohort of 64-year-old women, a group with IGT determined by repeated oral glucose tolerance tests (n=205) was compared with healthy women with normal glucose tolerance (NGT, n=188). Intima-media thickness (IMT) and plaques in the common carotid arteries (CCA) and bulbs were measured by ultrasound. The 95% confidence interval (CI) of the difference between the IGT and NGT groups was -0.03 to 0.03mm. There was no difference in carotid bulb IMT or in the occurrence, size, and characteristics of plaques between the IGT and NGT groups. A meta-analysis was used to calculate summary measures of 12 reviewed studies showing a difference of 0.030 (95% CI 0.012-0.048) mm in carotid IMT between IGT and NGT groups. Heterogeneity in IMT differences between studies was shown.
In our population-based cohort of 64-year-old women, IGT was not associated with increased occurrence of subclinical atherosclerosis. However, a meta-analysis of 12 studies, including our current study, showed that IGT was associated with a small increase in the CCA IMT.
糖耐量受损（IGT）被视为导致2型糖尿病的一种短暂代谢状态，并且已知其可预测未来心血管疾病风险。本研究旨在调查IGT是否与亚临床动脉粥样硬化相关。
在一个基于人群的64岁女性队列中，将通过重复口服葡萄糖耐量试验确定为IGT的一组（n = 205）与糖耐量正常（NGT）的健康女性（n = 188）进行比较。通过超声测量颈总动脉（CCA）及其球部的内膜中层厚度（IMT）和斑块。IGT组与NGT组之间差异的95%置信区间（CI）为-0.03至0.03mm。IGT组与NGT组在颈动脉球部IMT或斑块发生率、大小及特征方面无差异。采用荟萃分析计算12项综述研究的汇总指标，结果显示IGT组与NGT组颈动脉IMT差异为0.030（95%CI 0.012 - 0.048）mm。研究间IMT差异存在异质性。
在我们基于人群的64岁女性队列中，IGT与亚临床动脉粥样硬化发生率增加无关。然而，包括我们当前研究在内的12项研究的荟萃分析表明，IGT与CCA IMT的小幅增加相关。
