Reubi J C, Krenning E, Lamberts S W, Kvols L
Sandoz Research Institute, Berne, Switzerland.
J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1073-7. doi: 10.1016/0960-0760(90)90468-z.
High affinity somatostatin receptors (SS-R) have been identified in membrane homogenates or tissue sections from several hundred human tumors. SS-R were found in most tumors originating from SS target tissues, i.e. GH- and TSH-producing pituitary tumors, endocrine gastroenteropancreatic (GEP) tumors (including metastases) and brain tumors, including gliomas and neuroblastomas. SS-R were also expressed in several tumors originating from various other tissues, i.e. breast and small cell lung carcinomas, some colorectal cancers, and medullary thyroid carcinomas. In general, most of the SS-R+ tumors are well-differentiated and/or have neuroendocrine features. They often have low or absent epidermal growth factor receptor (EGF-R) expression. In some tumors (i.e. breast tumors) SS-R are not homogeneously distributed, making SS-R autoradiography a particularly useful tool for assessing SS-R status. SS-R are functional in pituitary and GEP tumors where they mediate hormone secretion inhibition. In these and in the other SS-R+ tumors, SS-R may also mediate antiproliferative effects of SS, as evidenced in animals where growth of SS-R+ tumor xenografts is inhibited by SS analogs. For diagnosis, SS-R+ tumors and metastases can be localized in vivo by scanning techniques after 123I-labelled SS analog injection.
在数百种人类肿瘤的膜匀浆或组织切片中已鉴定出高亲和力生长抑素受体（SS-R）。在大多数源自SS靶组织的肿瘤中发现了SS-R，即产生生长激素和促甲状腺激素的垂体肿瘤、内分泌胃肠胰腺（GEP）肿瘤（包括转移瘤）以及脑肿瘤，包括神经胶质瘤和神经母细胞瘤。SS-R也在源自其他各种组织的几种肿瘤中表达，即乳腺癌和小细胞肺癌、一些结直肠癌以及甲状腺髓样癌。一般来说，大多数SS-R阳性肿瘤分化良好和/或具有神经内分泌特征。它们通常表皮生长因子受体（EGF-R）表达低或无表达。在某些肿瘤（如乳腺肿瘤）中，SS-R分布不均匀，这使得SS-R放射自显影成为评估SS-R状态的特别有用的工具。SS-R在垂体和GEP肿瘤中起作用，在这些肿瘤中它们介导激素分泌抑制。在这些以及其他SS-R阳性肿瘤中，SS-R也可能介导SS的抗增殖作用，如在动物实验中所示，SS类似物可抑制SS-R阳性肿瘤异种移植物的生长。对于诊断，在注射123I标记的SS类似物后，可通过扫描技术在体内定位SS-R阳性肿瘤和转移瘤。
