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13-顺式维甲酸与放射治疗联合应用使广泛性非黑色素瘤皮肤癌迅速改善:三例报告

Rapid improvement of extensive non-melanoma skin cancers with combination of 13-cis-retinoic acid and radiotherapy: report of three cases.

作者信息

Danopoulou I, Korfitis C, Koliarakis N, Trafalis D T

机构信息

Department of Dermatology, "A. Sygros" Hospital, University of Athens, Athens, Greece.

出版信息

J BUON. 2009 Jul-Sep;14(3):515-7.

PMID:19810148
Abstract

Extensive non-melanoma skin cancer (NMSC) constitutes a therapeutic challenge especially in old and debilitated patients. Applied treatments include surgical excision, MOHS micrographic surgery, cryosurgery, electrodesiccation, and radiotherapy. We present 3 elderly patients with extensive basal or squamous cell carcinomas and poor general condition who were treated with a combination of 13-cis-retinoic acid 1 mg/kg daily and radiotherapy 2.5 Gy daily. The treatment resulted in rapid improvement of the tumors with significant reduction of their size.

摘要

广泛性非黑素瘤皮肤癌(NMSC)构成了一项治疗挑战,尤其是在老年和体弱患者中。应用的治疗方法包括手术切除、莫氏显微外科手术、冷冻手术、电干燥法和放射疗法。我们报告了3例患有广泛性基底细胞癌或鳞状细胞癌且全身状况较差的老年患者,他们接受了每日1毫克/千克的13-顺式维甲酸与每日2.5戈瑞放射疗法联合治疗。治疗使肿瘤迅速改善,其大小显著减小。

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