Labia R, Beguin-Billecoq R, Guionie M
CNRS-CERCOA, B.P. 28, 94320 Thiais, France.
J Antimicrob Chemother. 1981 Sep;8 Suppl B:141-6. doi: 10.1093/jac/8.suppl_b.141.
from Escherichia coli, Enterobacter cloacae, Proteus morganii and Pseudomonas aeruginosa, but the geometric mean of the inhibition constant Ki used to measure this interaction was 120 and almost 700 times higher with ceftazidime than with cefotaxime and cefuroxime, respectively. Two other beta-lactamases isolated from Pr. vulgaris and Klebsiella oxytoca also showed little or no interaction with ceftazidime. A complementary microbiological technique, the "double-disc" technique, indicated that ceftazidime was more stable than cefotaxime to all beta-lactamases tested. Moxalactam, however, appeared to have slightly greater stability.
来自大肠杆菌、阴沟肠杆菌、摩根氏变形杆菌和铜绿假单胞菌，但用于测量这种相互作用的抑制常数Ki的几何平均值为120，与头孢他啶相比，分别几乎是头孢噻肟和头孢呋辛的700倍。从普通变形杆菌和产酸克雷伯菌中分离出的另外两种β-内酰胺酶与头孢他啶也几乎没有相互作用。一种补充性微生物技术，即“双纸片”技术，表明头孢他啶对所有测试的β-内酰胺酶都比头孢噻肟更稳定。然而，拉氧头孢似乎稳定性略高。
