Eastern Virginia Medical School, Norfolk, Virginia, USA.
Climacteric. 2009;12 Suppl 1:26-31. doi: 10.1080/13697130903013452.
Premature menopause and bilateral oophorectomy in young women are associated with an increased incidence of cardiovascular disease, myocardial infarction and overall mortality. Observational studies suggest an interval of 5-10 years between loss of ovarian function and the increased risk of cardiovascular disease. This finding is consonant with a published autopsy study of women who had undergone bilateral oophorectomy. The progression of atherosclerosis is retarded with the use of estrogen replacement therapy in non-human primates and women. Hormone therapy reduced the incidence of cardiovascular disease in women following bilateral oophorectomy. These findings support the use of hormone therapy in young women who have lost ovarian function.
年轻女性的过早绝经和双侧卵巢切除术与心血管疾病、心肌梗死和总死亡率的发生率增加有关。观察性研究表明，卵巢功能丧失与心血管疾病风险增加之间存在 5-10 年的间隔。这一发现与对接受双侧卵巢切除术的女性进行的已发表的尸检研究结果一致。在非人类灵长类动物和女性中，使用雌激素替代疗法可以延缓动脉粥样硬化的进展。激素疗法降低了双侧卵巢切除术后女性心血管疾病的发病率。这些发现支持对失去卵巢功能的年轻女性使用激素疗法。
