Lindau Dennis, Decker Patrice
Department of Immunology, Institute for Cell Biology, University of Tübingen, Tübingen, Germany.
Autoimmunity. 2009 May;42(4):254-6. doi: 10.1080/08916930902827884.
Nucleosomes (Nuc) are key lupus autoantigen and have been shown to activate several types of immune cells as well as the complement system, resulting in inflammation. The elevated concentrations and the immunostimulatory capacities of circulating Nuc may favour the break of peripheral tolerance in genetically predisposed individuals. Nevertheless, in most cases the signalling pathways involved are not elucidated yet, although Tir8/Sigirr deficiency has been recently shown to enhance cell activation upon exposure to Nuc-containing immune complexes.
核小体（Nuc）是关键的狼疮自身抗原，已被证明可激活多种免疫细胞以及补体系统，从而导致炎症。循环核小体浓度升高及其免疫刺激能力可能有利于遗传易感性个体外周耐受的打破。然而，尽管最近研究表明Tir8/Sigirr缺陷会增强细胞在接触含核小体免疫复合物时的激活，但在大多数情况下，其中涉及的信号通路仍未阐明。
