Schildkopf Petra, Holmer Reinhild, Sieber Renate, Ott Oliver J, Janko Christina, Mantel Frederick, Frey Benjamin, Fietkau Rainer, Gaipl Udo S
Department of Radiation Oncology, University of Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Universitätsstrausse 27, 91054, Erlangen, Germany.
Autoimmunity. 2009 May;42(4):311-3. doi: 10.1080/08916930902832041.
Autoimmune diseases and cancer can be treated by influencing the immune system. Apo and nec cells are strong modulators of the immune system contributing to anti-inflammatory and pro-inflammatory responses, respectively. We examined which form of cell death was induced by HT and X-irradiation. Nec was the prominent form of cell death after combined treatment and the amount of dead cells was higher when exposing the cells to radiation before HT. Combined applications further led to an increased percentage of cells in a more radioresponsive G2 cell cycle phase. The danger signal HMGB1 is released when combining HT with radiation, a further hint that those treatments may induce inflammation and immune activation. We conclude that immune responses are appropriately adapted to the damage that has occurred and may contribute to anti-cancer immunity or chronic autoimmunity, respectively.
自身免疫性疾病和癌症可以通过影响免疫系统来治疗。凋亡细胞和坏死细胞是免疫系统的强效调节剂，分别有助于抗炎和促炎反应。我们研究了热疗（HT）和X射线照射诱导的细胞死亡形式。联合治疗后，坏死是主要的细胞死亡形式，并且在热疗前对细胞进行辐射时，死亡细胞的数量更高。联合应用还导致处于更具放射反应性的G2细胞周期阶段的细胞百分比增加。热疗与辐射联合时会释放危险信号高迁移率族蛋白B1（HMGB1），这进一步表明这些治疗可能会诱导炎症和免疫激活。我们得出结论，免疫反应会根据已发生的损伤进行适当调整，分别可能有助于抗癌免疫或慢性自身免疫。
