Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea.
Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul 05006, Korea.
Int J Mol Sci. 2018 Sep 17;19(9):2795. doi: 10.3390/ijms19092795.
Hyperthermia is a cancer treatment where tumor tissue is heated to around 40 °C. Hyperthermia shows both cancer cell cytotoxicity and immune response stimulation via immune cell activation. Immunogenic responses encompass the innate and adaptive immune systems, involving the activation of macrophages, natural killer cells, dendritic cells, and T cells. Moreover, hyperthermia is commonly used in combination with different treatment modalities, such as radiotherapy and chemotherapy, for better clinical outcomes. In this review, we will focus on hyperthermia-induced immunogenic effects and molecular events to improve radiotherapy efficacy. The beneficial potential of integrating radiotherapy with hyperthermia is also discussed.
热疗是一种癌症治疗方法，通过将肿瘤组织加热至约 40°C 来实现。热疗通过激活免疫细胞来显示出对癌细胞的细胞毒性和免疫反应刺激。免疫原性反应包括先天和适应性免疫系统，涉及巨噬细胞、自然杀伤细胞、树突状细胞和 T 细胞的激活。此外，热疗通常与不同的治疗方式结合使用，如放疗和化疗，以获得更好的临床效果。在这篇综述中，我们将重点关注热疗诱导的免疫原性效应和分子事件，以提高放疗疗效。还讨论了将放疗与热疗相结合的有益潜力。
