Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, IFIByNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires C1428EHA, Argentina.
Anim Cogn. 2010 May;13(3):391-403. doi: 10.1007/s10071-009-0288-y. Epub 2009 Oct 8.
A decline in the frequency or intensity of a conditioned behavior following the withdrawal of the reinforcement is called experimental extinction. However, the experimental manipulation necessary to trigger memory reconsolidation or extinction is to expose the animal to the conditioned stimulus in the absence of reinforcement. Recovery protocols were used to reveal which of these two processes was developed. By using the crab contextual memory model (a visual danger stimulus associated with the training context), we investigated the dynamics of extinction memory in Chasmagnathus. Here, we reveal the presence of three recovery protocols that restore the original memory: the old memory comes back 4 days after the extinction training, or when a weak training is administered later, or once the VDS is presented in a novel context 24 h after the extinction session. Another objective was to evaluate whether the administration of multi-trial extinction training could trigger an extinction memory in Chasmagnathus. The results evince that the extinction memory appears only when the total re-exposure time is around 90 min independently of the number of trials employed to accumulate it. Thus, it is feasible that the mechanisms described for the case of the extinction memory acquired through a single training trial are valid for multi-trial extinction protocols. Finally, these results are in agreement with those reports obtained with models phylogenetically far apart from the crab. Behind this attempt is the idea that in the domain of studies on memory, some principles of behavior organization and basic mechanisms have universal validity.
一种条件行为的频率或强度下降，在强化物撤回后被称为实验性消退。然而，触发记忆再巩固或消退的实验操作是使动物在没有强化物的情况下暴露于条件刺激。恢复方案被用来揭示这两种过程中的哪一种得到了发展。通过使用蟹类情境记忆模型（与训练情境相关的视觉危险刺激），我们研究了 Chasmagnathus 中消退记忆的动态。在这里，我们揭示了三种恢复方案的存在，这些方案可以恢复原始记忆：在消退训练后 4 天，或者当进行较弱的训练时，或者当 VDS 在消退会议后 24 小时在新的情境中呈现时，原始记忆会恢复。另一个目的是评估多次消退训练的实施是否可以在 Chasmagnathus 中引发消退记忆。结果表明，只有当总重暴露时间约为 90 分钟时，消退记忆才会出现，而与用于积累它的试验次数无关。因此，通过单次训练试验获得的消退记忆的机制对于多试验消退方案有效是可行的。最后，这些结果与从进化上远离蟹类的模型获得的报告一致。这一尝试背后的想法是，在记忆研究领域，一些行为组织原则和基本机制具有普遍的有效性。
