Zhang Jinlong, Luo Qinglu, He Chengqi, Yang Lin, He Hongchen, Wu Yuanchao, Xie Wei, Xiong Enfu
Department of Rehabilitation, West China Hospital, Sichuan Uniersity, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2009 Aug;26(4):852-5, 860.
For the purpose of identifying the effect of body mass index on bone mineral density, an investigation was made in regard to the relationship between body mass index (BMI), bone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebrals of men without osteoporosis. 838 male patients were diagnosed and treated in West China Hospital of Sichuan University because of ostealgia and arthralgia from Aug. 2003 to Dec. 2005. They were examined by dual-energy X-ray absorptiometry, their L2-L4 bone mineral density being < -2.5SD. Then they were graded by body mass index (Kg/m2) [1st group BMI > or =23, 454 cases (Group A BMI > or = 29, 46 cases; Group B 25 < or = BMI < 28.9, 201 cases; Group C 23 < or = BMI < 24, 9193 cases); 2nd group 18.5 < BMI < 22.9, 311 cases; 3rd group BMI < or = 18.5, 68 cases]. The relationships between BMI and BMD of lumbar spine were analyzed using SPSS 13.0. The results revealed their positions in series: (1) Among Groups 1-3, BMD, average BMD and aBMC of L2-L4 being 3rd group > 2nd group > 1st group, the differencs are statistically significant (P < 0.05 or P < 0.01); BMC, aBMC of L3 and L4 and aBMC of L2 being 3rd group > 2nd group > 2nd group, the differences are significant (P < 0.01); besides BMC of L2 and T-score,the differencs among three groups are not statistically significant (P > 0.05); (2) Among the 1st group, BMD and average BMD of L2-L4 being Group C > Group B > Group A,the differencs are significant (P < 0.05 or P < 0.01); BMC, aBMC of L and I being Group C > Group B > Group A,the differences among the three groups are significant (P < 0.05 or P < 0.01); BMC, aBMC of L3 and L4 and aBMC of L2 being Group C > Group B > Group A, the differences are significant, besides BMC of L2 and T-score,the differences among three groups are not significant (P > 0.05), (3) BMI correlated negatively (P < 0.01, r = -0.189) to the average BMD of lumbar spine. The average BMD of lumbar spine decreases when BMI increases in males without osteoporosis. When obesity is more obvious, the decrease in average BMD of lumbar spine bone is more evidently decreased. The decrease of BMD, BMC and total BMC in L3 and L may be greater than that in L2.
为了确定体重指数对骨密度的影响，对无骨质疏松症男性腰椎的体重指数（BMI）、骨密度（BMD）和骨矿物质含量（BMC）之间的关系进行了调查。2003年8月至2005年12月，838例因骨痛和关节痛在四川大学华西医院诊断治疗的男性患者，采用双能X线吸收法进行检查，其L2-L4骨密度＜-2.5SD。然后根据体重指数（kg/m2）进行分组[第1组BMI≥23，454例（A组BMI≥29，46例；B组25≤BMI＜28.9，201例；C组23≤BMI＜24，93例）；第2组18.5＜BMI＜22.9，311例；第3组BMI≤18.5，68例]。使用SPSS 13.0分析BMI与腰椎BMD之间的关系。结果显示它们的顺序为：（1）在第1-3组中，L2-L4的BMD、平均BMD和aBMC为第3组＞第2组＞第1组，差异有统计学意义（P＜0.05或P＜0.01）；BMC、L3和L4的aBMC以及L2的aBMC为第3组＞第2组＞第1组，差异有统计学意义（P＜0.01）；除L2的BMC和T值外，三组之间的差异无统计学意义（P＞0.05）；（2）在第1组中，L2-L4的BMD和平均BMD为C组＞B组＞A组，差异有统计学意义（P＜0.05或P＜0.01）；BMC、L和I的aBMC为C组＞B组＞A组，三组之间的差异有统计学意义（P＜0.05或P＜0.01）；BMC、L3和L4的aBMC以及L2的aBMC为C组＞B组＞A组，差异有统计学意义，除L2的BMC和T值外，三组之间的差异无统计学意义（P＞0.05）；（3）BMI与腰椎平均BMD呈负相关（P＜0.01，r=-0.189）。无骨质疏松症男性中，BMI升高时腰椎平均BMD降低。肥胖越明显，腰椎骨平均BMD降低越明显。L3和L的BMD、BMC和总BMC的降低可能大于L2。
