Vaalasti A, Suomalainen H, Kuokkanen K, Rechardt L
Department of Dermatology, Tampere University Central Hospital, Finland.
J Cutan Pathol. 1990 Dec;17(6):371-3. doi: 10.1111/j.1600-0560.1990.tb00114.x.
The occurrence of neuropeptides was studied in neurofibromas of von Recklinghausen's disease by indirect immunofluorescence. All non-plexiform cutaneous neurofibromas contained abundant vasoactive intestinal polypeptide, peptide histidine-isoleucine and calcitonin gene-related peptide immunoreactive nerves. The nerves were small and unmyelinated. Neuropeptides might be responsible for itch that occurs especially in small cutaneous neurofibromas. Neuropeptides are also suggested to act as modulators and/or trophic factors for neurofibroma growth.
通过间接免疫荧光法研究了冯·雷克林霍增氏病神经纤维瘤中神经肽的出现情况。所有非丛状皮肤神经纤维瘤均含有丰富的血管活性肠多肽、肽组氨酸异亮氨酸及降钙素基因相关肽免疫反应性神经。这些神经细小且无髓鞘。神经肽可能是导致瘙痒的原因，尤其是在小型皮肤神经纤维瘤中出现的瘙痒。神经肽也被认为可作为神经纤维瘤生长的调节因子和/或营养因子。
