• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

药物遗传学——日益接近。

Pharmacogenetics - getting closer.

作者信息

Macdonald Ian M

机构信息

Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada.

出版信息

Open Ophthalmol J. 2009 Sep 17;3:46-9. doi: 10.2174/1874364100903020046.

DOI:10.2174/1874364100903020046
PMID:19816587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2759118/
Abstract

This review is written for the generalist to provide an understanding of the application of genetics to the care of patients with glaucoma and the broader concepts of personalized medicine. More specifically, the review will link advances in the genetics of glaucoma with the concepts of pharmacogenetics and its potential to improve patient care.

摘要

本综述是为全科医生撰写的，旨在让他们了解遗传学在青光眼患者护理中的应用以及个性化医疗的更广泛概念。更具体地说，本综述将把青光眼遗传学的进展与药物遗传学的概念及其改善患者护理的潜力联系起来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb9a/2759118/240afa1c9b81/TOOPHTJ-3-46_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb9a/2759118/240afa1c9b81/TOOPHTJ-3-46_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb9a/2759118/240afa1c9b81/TOOPHTJ-3-46_F1.jpg

相似文献

1
Pharmacogenetics - getting closer.药物遗传学——日益接近。
Open Ophthalmol J. 2009 Sep 17;3:46-9. doi: 10.2174/1874364100903020046.
2
Genetics and genomics: the scientific drivers of personalized medicine.遗传学与基因组学：个性化医疗的科学驱动力。
Annu Rev Nurs Res. 2011;29:27-54. doi: 10.1891/0739-6686.29.27.
3
"" Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era.如果我们在性别组学和性组学时代应用性别医学、药物基因组学和个性化医学，那么所有这些本都可以避免。
Int J Mol Sci. 2019 Dec 31;21(1):296. doi: 10.3390/ijms21010296.
4
Pharmacogenetics--genomics and personalized psychiatry.药物遗传学——基因组学与个性化精神病学。
Eur Psychiatry. 2010 Jun;25(5):291-3. doi: 10.1016/j.eurpsy.2009.12.015. Epub 2010 Apr 13.
5
The impact of pharmacogenetics and pharmacogenomics on drug discovery.
Nat Rev Drug Discov. 2002 Jun;1(6):463-9. doi: 10.1038/nrd823.
6
Pharmacogenetics/genomics and personalized medicine.药物遗传学/基因组学与个性化医疗。
Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R207-14. doi: 10.1093/hmg/ddi261.
7
Pharmacogenetics: An Important Part of Drug Development with A Focus on Its Application.药物遗传学：药物研发的重要组成部分及其应用聚焦
Int J Biomed Investig. 2018;1(2). doi: 10.31531/2581-4745.1000111. Epub 2018 May 27.
8
The faces of personalized medicine: a framework for understanding its meaning and scope.个性化医学的面貌：理解其含义和范围的框架。
Value Health. 2013 Sep-Oct;16(6 Suppl):S4-9. doi: 10.1016/j.jval.2013.06.005.
9
Fundamentals of Pharmacogenetics in Personalized, Precision Medicine.个性化精准医学中的药物遗传学基础
Clin Lab Med. 2016 Sep;36(3):447-59. doi: 10.1016/j.cll.2016.05.006. Epub 2016 Jul 2.
10
Personalized medicine policy challenges: measuring clinical utility at point of care.个性化医学政策面临的挑战：在护理点衡量临床效用。
Expert Rev Pharmacoecon Outcomes Res. 2012 Jun;12(3):289-95. doi: 10.1586/erp.12.15.

引用本文的文献

1
Genetic diversity and medicinal drug response in eye care.眼部护理中的遗传多样性和药物反应。
Graefes Arch Clin Exp Ophthalmol. 2010 Aug;248(8):1057-61. doi: 10.1007/s00417-010-1333-x. Epub 2010 Mar 5.

本文引用的文献

1
Intraocular pressure response to topical beta-blockers associated with an ADRB2 single-nucleotide polymorphism.眼压对与ADRB2单核苷酸多态性相关的局部β受体阻滞剂的反应。
Arch Ophthalmol. 2008 Jul;126(7):959-63. doi: 10.1001/archopht.126.7.959.
2
Exfoliation syndrome and exfoliation glaucoma-associated LOXL1 variations are not involved in pigment dispersion syndrome and pigmentary glaucoma.剥脱综合征及与剥脱性青光眼相关的赖氨酰氧化酶样蛋白1（LOXL1）变异与色素播散综合征及色素性青光眼无关。
Mol Vis. 2008 Jul 9;14:1254-62.
3
Keeping pace with the times--the Genetic Information Nondiscrimination Act of 2008.
与时俱进——2008年《遗传信息非歧视法案》
N Engl J Med. 2008 Jun 19;358(25):2661-3. doi: 10.1056/NEJMp0803964.
4
Personalized medicine and the practice of medicine in the 21st century.个性化医疗与21世纪的医学实践。
Mcgill J Med. 2007 Jan;10(1):53-7.
5
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.在三个不同人群中，赖氨酰氧化酶样蛋白1（LOXL1）变体与原发性开角型青光眼之间不存在关联。
Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3465-8. doi: 10.1167/iovs.08-1850. Epub 2008 Apr 17.
6
Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma.剥脱综合征和剥脱性青光眼中LOXL1基因多态性的评估。
Mol Vis. 2008 Mar 17;14:533-41.
7
Role of CYP1B1 in glaucoma.细胞色素P450 1B1（CYP1B1）在青光眼发病机制中的作用。
Annu Rev Pharmacol Toxicol. 2008;48:333-58. doi: 10.1146/annurev.pharmtox.48.061807.154729.
8
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.赖氨酰氧化酶样蛋白1（LOXL1）基因中的常见序列变异会增加剥脱性青光眼的易感性。
Science. 2007 Sep 7;317(5843):1397-400. doi: 10.1126/science.1146554. Epub 2007 Aug 9.
9
Primary-open glaucoma and myopia: a narrative review.原发性开角型青光眼与近视：一项叙述性综述
WMJ. 2007 Apr;106(2):85-9, 95.
10
Association between genetic polymorphisms of the prostaglandin F2alpha receptor gene and response to latanoprost.前列腺素F2α受体基因的基因多态性与拉坦前列素反应之间的关联。
Ophthalmology. 2007 Jun;114(6):1039-45. doi: 10.1016/j.ophtha.2007.03.025. Epub 2007 Apr 30.