Nitsch C, Riesenberg R
Anatomical Institute, University of Basle.
Acta Histochem Suppl. 1990;38:161-71.
In rat hippocampus, the opioid peptide dynorphin A (1-17) is present in a subpopulation of the mossy fiber terminals, as shown by ultrastructural immunocytochemistry. The immunoreactive boutons exhibit all features characteristic for giant mossy fiber boutons, as e.g. inclusions of neighboring giant boutons which may or may not be dynorphin A-positive. At early survival times after selective lesioning the mossy fiber system with colchicine, lysosomes indicative for the proceeding degeneration are present in boutons still immunoreactive for dynorphin A as well as in non-immunoreactive boutons. This observation provides evidence that the dynorphinergic terminals are in fact the endings of the granule cells.
在大鼠海马体中，阿片肽强啡肽A（1-17）存在于苔藓纤维终末的一个亚群中，超微结构免疫细胞化学已证实这一点。免疫反应阳性的终扣呈现出巨型苔藓纤维终扣的所有特征，例如包含相邻的巨型终扣，这些相邻终扣可能是强啡肽A阳性，也可能不是。在用秋水仙碱选择性损伤苔藓纤维系统后的早期存活时间，表明正在发生退变的溶酶体存在于对强啡肽A仍有免疫反应的终扣以及无免疫反应的终扣中。这一观察结果证明，含强啡肽的终末实际上是颗粒细胞的终末。
