Third Medical Department, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany.
Trends Endocrinol Metab. 2010 Feb;21(2):111-22. doi: 10.1016/j.tem.2009.09.001. Epub 2009 Oct 12.
Glycoprotein hormone receptors (GPHRs) are members of the seven-transmembrane-spanning receptor family characterized by a large ectodomain. The hinge region belongs to a part of the GPHR ectodomain for which the three-dimensional structure has not yet been deciphered, leaving important questions unanswered concerning ligand binding and GPHR activation. Recent publications indicate that specific residues of the hinge region mediate hormone binding, receptor activation and/or intramolecular signaling for the three GPHRs, emphasizing the importance of this region. Based on these findings, the hinge region is involved at least in part in hormone binding and receptor activation. This review summarizes functional data regarding the hinge region, demonstrating that this receptor portion represents a link between ligand binding and subsequent GPHR activation.
糖蛋白激素受体 (GPHR) 是七跨膜受体家族的成员，其特征是具有大的细胞外结构域。铰链区属于 GPHR 细胞外结构域的一部分，其三维结构尚未被破译，这使得关于配体结合和 GPHR 激活的重要问题仍未得到解答。最近的出版物表明，铰链区的特定残基介导三种 GPHR 的激素结合、受体激活和/或分子内信号转导，强调了该区域的重要性。基于这些发现，铰链区至少部分参与激素结合和受体激活。本综述总结了关于铰链区的功能数据，证明该受体部分是配体结合和随后的 GPHR 激活之间的联系。
