Department of Pediatric Intensive Care, Faculty of Medicine, Mersin University, Mersin, Turkey.
J Trop Pediatr. 2010 Jun;56(3):195-7. doi: 10.1093/tropej/fmp094. Epub 2009 Oct 9.
The purpose of this study was to evaluate left and right ventricular functions by using the Doppler myocardial performance index (MPI), in children with sickle cell anemia (SCA).
We examined 32 patients with SCA and 30 age-matched healthy children. Echocardiography and Doppler examinations were completed for each of the subjects. MPI was calculated from the Doppler tracings.
Compared with controls, left ventricle (LV) end-diastolic diameter, end-systolic diameter, early-diastolic mitral flow velocity and late-diastolic mitral flow velocity were significantly higher in the patients with SCA. Although, the LV ejection fractions were in the normal ranges in patients and controls, both LV and right ventricle (RV) MPI were significantly higher in patients than those in normal children.
MPI may be a useful noninvasive and sensitive tool for assessing the sub-clinical cardiac LV and RV dysfunctions in patients with SCA.
本研究旨在通过多普勒心肌做功指数（MPI）评估镰状细胞贫血（SCA）患儿的左、右心室功能。
我们检查了 32 例 SCA 患儿和 30 名年龄匹配的健康儿童。对每位受试者进行超声心动图和多普勒检查。从多普勒迹线计算 MPI。
与对照组相比，SCA 患儿的左心室（LV）舒张末期直径、收缩末期直径、二尖瓣舒张早期流速和二尖瓣舒张晚期流速明显更高。尽管 LV 射血分数在患者和对照组均处于正常范围内，但患者的 LV 和右心室（RV）MPI 均明显高于正常儿童。
MPI 可能是一种有用的非侵入性和敏感的工具，可用于评估 SCA 患者亚临床的 LV 和 RV 心功能障碍。
