Odey Friday, Okomo Uduak, Oyo-Ita Angela
Department of Paediatrics, University of Calabar Teaching Hospital, PMB 1115, Calabar, Cross River State, Nigeria.
Cochrane Database Syst Rev. 2009 Oct 7(4):CD006975. doi: 10.1002/14651858.CD006975.pub2.
Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines.
To determine whether routine administration of salmonella vaccines to people with sickle cell disease reduces the morbidity and mortality associated with infection.
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises of references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.We also conducted a search of the LILACS database.Date of most recent search of the Group's Haemoglobinopathies Trials Register: 17 June 2009.
We planned to select all randomized controlled trials that compared the use of either the inactivated vaccine or an oral attenuated vaccine with a placebo among people with sickle cell disease. Equally, studies that compared the efficacy of one vaccine type over another were to be selected for the review.
No trials of salmonella vaccines in people with sickle cell disease were found.
There is an absence of randomized controlled trial evidence relating to the scope of this review.
AUTHORS' CONCLUSIONS: It is expected that salmonella vaccines may be useful in people with sickle cell disease, especially in resource-poor settings where the majority of those who suffer from the condition are found. Unfortunately, there are no randomized controlled trials on the efficacy and safety of the different types of salmonella vaccines in people with sickle cell disease. We conclude that there is a need for a well-designed, adequately-powered, randomized controlled trial to assess the benefits and risks of the different types of salmonella vaccines as a means of improving survival and decreasing mortality from salmonella infections in people with sickle cell disease.
沙门氏菌感染是镰状细胞病患者（尤其是儿童）侵袭性疾病的常见细菌病因，且与高发病率和死亡率相关。尽管某些中心有沙门氏菌疫苗，但镰状细胞贫血患者通常未接种该疫苗。
确定对镰状细胞病患者常规接种沙门氏菌疫苗是否能降低与感染相关的发病率和死亡率。
我们检索了Cochrane囊性纤维化和遗传疾病组试验注册库，该注册库包含从全面电子数据库检索、相关期刊手工检索以及会议论文摘要书籍中识别出的参考文献。我们还检索了LILACS数据库。该组血红蛋白病试验注册库的最新检索日期为2009年6月17日。
我们计划选择所有比较灭活疫苗或口服减毒疫苗与安慰剂在镰状细胞病患者中使用情况的随机对照试验。同样，比较一种疫苗类型优于另一种疫苗类型疗效的研究也将被选入综述。
未找到关于镰状细胞病患者使用沙门氏菌疫苗的试验。
缺乏与本综述范围相关的随机对照试验证据。
预计沙门氏菌疫苗可能对镰状细胞病患者有用，尤其是在资源匮乏地区，那里有大多数患有该病的患者。不幸的是，尚无关于不同类型沙门氏菌疫苗在镰状细胞病患者中的疗效和安全性的随机对照试验。我们得出结论，需要进行一项设计良好、样本量充足的随机对照试验，以评估不同类型沙门氏菌疫苗的益处和风险，作为提高镰状细胞病患者生存率和降低沙门氏菌感染死亡率的一种手段。
