Shih Andre, Giguère Steeve, Sanchez L Chris, Valverde Alexander, Bandt Carsten, Jankunas Hope, Robertson Sheilah
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
J Vet Emerg Crit Care (San Antonio). 2009 Oct;19(5):438-43. doi: 10.1111/j.1476-4431.2009.00461.x.
To compare cardiac output (CO) measured by use of lithium dilution (LiDCO) and ultrasound velocity dilution (UDCO) in conditions of high, intermediate, and low CO in anesthetized foals.
Original prospective study.
University teaching hospital.
Six foals 1-3 days of age (38-45 kg).
Neonatal foals were anesthetized and instrumented to measure direct blood pressure, heart rate, arterial blood gases, and CO. The CO was measured by use of LiDCO and UDCO techniques. Measurements were obtained from each foal at baseline and during low, intermediate, and high CO states. Measurements were converted to cardiac index (cardiac index=CO/body weight) values for statistical analysis. Agreement between the 2 methods was determined using Bland and Altman analysis and concordance correlation coefficients.
LiDCO determinations of CO ranged between 4.0 and 14.0 L/min resulting in cardiac index ranging between 75.5 and 310 mL/kg/min. There was no significant effect of blood pressure variation on bias or relative bias (P=0.62 and 0.93, respectively). The mean bias and relative bias of UDCO (+/-SD) compared with LiDCO were -20.1+/-39.2 mL/kg/min and -7.7+/-23.4%, respectively. Concordance correlation coefficient between LiDCO and UDCO was 0.833.
When compared with LiDCO, the UDCO technique has acceptable clinical utility for measuring CO in healthy anesthetized newborn foals.
比较在麻醉小马驹处于高、中、低心输出量（CO）状态下，使用锂稀释法（LiDCO）和超声速度稀释法（UDCO）测量心输出量的情况。
原始前瞻性研究。
大学教学医院。
6匹1 - 3日龄的小马驹（体重38 - 45千克）。
对新生小马驹进行麻醉并安装仪器以测量直接血压、心率、动脉血气和心输出量。使用LiDCO和UDCO技术测量心输出量。在基线以及低、中、高CO状态下从每匹小马驹获取测量值。将测量值转换为心脏指数（心脏指数 = 心输出量/体重）值进行统计分析。使用布兰德 - 奥特曼分析和一致性相关系数确定两种方法之间的一致性。
LiDCO测定的心输出量范围为4.0至14.0升/分钟，导致心脏指数范围为75.5至310毫升/千克/分钟。血压变化对偏差或相对偏差无显著影响（P分别为0.62和0.93）。与LiDCO相比，UDCO的平均偏差和相对偏差（±标准差）分别为 - 20.1±39.2毫升/千克/分钟和 - 7.7±23.4%。LiDCO和UDCO之间的一致性相关系数为0.833。
与LiDCO相比，UDCO技术在测量健康麻醉新生小马驹的心输出量方面具有可接受的临床实用性。
