Histology and Embryology Department, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Wound Repair Regen. 2009 Nov-Dec;17(6):825-31. doi: 10.1111/j.1524-475X.2009.00542.x. Epub 2009 Oct 12.
To examine the influence of therapeutic ultrasound (US) on repair of standard and ischemic cutaneous lesions, full-thickness excisional wounds were made in rats and treated with a US 3 MHz, 0.5 W/cm(2) pulsed duty cycle. We used five experimental groups: control (received US powered off on the day of surgery, and on the second and fourth day), control US (received US on the day of surgery, and on the second and fourth day), ischemic (received US powered off on the day of surgery, and on the second and fourth day), ischemic US 3X (received US on the day of surgery, and on the second and fourth day) and ischemic US 5X (received US in the day of surgery, first, second, third and fourth day). The control US group showed acceleration in wound contraction 7 days after wounding, an increase in collagen density, and only focal inflammatory areas. Neo-epidermis formation was more advanced in the control US group than in the control one. Wound contraction was delayed in the ischemic group when compared with the control group as well as the ischemic US 3X group, was but slightly accelerated in the ischemic US 5X group when compared with the ischemic group 7 days after wounding. Reepithelialization was delayed in both ischemic US groups when compared with the ischemic group. The number of inflammatory cells was higher in both US ischemic groups. We conclude that US therapy accelerates wound healing in normal wounds and delays wound healing in ischemic wounds.
为了研究治疗性超声（US）对标准和缺血性皮肤病变修复的影响，在大鼠身上制作了全层切除伤口，并使用 3 MHz、0.5 W/cm(2)的脉冲占空比进行 US 治疗。我们使用了五个实验组：对照组（手术当天、第 2 天和第 4 天关闭 US 治疗，接受 US 治疗）、对照 US 组（手术当天、第 2 天和第 4 天接受 US 治疗）、缺血组（手术当天、第 2 天和第 4 天关闭 US 治疗）、缺血 US 3X 组（手术当天、第 2 天和第 4 天接受 US 治疗）和缺血 US 5X 组（手术当天、第 1 天、第 2 天、第 3 天和第 4 天接受 US 治疗）。对照组在受伤后 7 天内显示出伤口收缩的加速，胶原密度增加，仅有局部炎症区。与对照组相比，对照 US 组的新生表皮形成更为先进。与对照组和缺血 US 3X 组相比，缺血组的伤口收缩延迟，但在受伤后 7 天，缺血 US 5X 组的伤口收缩略有加速。与缺血组相比，两个缺血 US 组的再上皮化均延迟。两个缺血 US 组的炎症细胞数量均较高。我们得出结论，US 治疗加速了正常伤口的愈合，延迟了缺血性伤口的愈合。
