Gerges E, Gertner S B
Department of Pharmacology and Toxicology, New Jersey Medical School, UMDNJ, Newark 07103.
Agents Actions. 1990 Nov;31(3-4):243-8. doi: 10.1007/BF01997615.
Central administration of histamine in conscious rats produced half the pressor response in hypophysectomized rats compared to normal animals. The pressor response was blocked completely by hexamethonium in hypophysectomized rats but not at all in normal rats. Homodimaprit given centrally, gave pressor effects of equal magnitude in both groups. In normal rats, it caused significantly higher blood blood pressure following ganglionic blockade, whereas in hypophysectomized rats hexamethonium did not block the response to homodimaprit. These results, plus previous findings, show that histamine, given centrally, raises blood pressure in normal conscious animals by releasing vasoactive substances from the brain. In hypophysectomized rats it stimulates sympathetic output. Homodimaprit, on the other hand, produces its pressor action by the release of vasoactive substances from the brain both in normal and hypophysectomized animals. A hypothesis is proposed to suggest that parallel neuronal processing occurs in the brain when histamine is given.
与正常动物相比，向清醒大鼠中枢给予组胺后，垂体切除大鼠的升压反应仅为正常动物的一半。在垂体切除大鼠中，六甲铵可完全阻断升压反应，但在正常大鼠中则完全无此作用。向中枢给予高莫普立特，两组大鼠均出现同等程度的升压效应。在正常大鼠中，神经节阻断后其血压显著升高，而在垂体切除大鼠中，六甲铵并未阻断对高莫普立特的反应。这些结果以及先前的研究发现表明，向中枢给予组胺可通过从脑内释放血管活性物质来升高正常清醒动物的血压。在垂体切除大鼠中，它刺激交感神经输出。另一方面，无论在正常动物还是垂体切除动物中，高莫普立特均通过从脑内释放血管活性物质来产生其升压作用。有人提出一种假说，认为给予组胺时脑内会发生平行神经元加工过程。
