Zhu Feng, Loh Marie, Hill Jeffrey, Lee Sumarlin, Koh King Xin, Lai Kin Wai, Salto-Tellez Manuel, Iacopetta Barry, Yeoh Khay Guan, Soong Richie
Department of Medicine, National University of Singapore, Singapore, Singapore.
BMC Gastroenterol. 2009 Oct 13;9:76. doi: 10.1186/1471-230X-9-76.
Intestinal metaplasia (IM) is an important precursor lesion in the development of gastric cancer (GC). The aim of this study was to investigate genetic factors previously linked to GC risk for their possible association with IM. A total of 18 polymorphisms in 14 candidate genes were evaluated in a Singapore-Chinese population at high risk of developing GC.
Genotype frequencies were compared between individuals presenting with (n = 128) or without (n = 246) IM by both univariate and multivariate analysis.
Carriers of the NQO1 609 T allele showed an association with IM in individuals who were seropositive for Helicobacter pylori (HP+; OR = 2.61, 95%CI: 1.18-5.80, P = .018). The IL-10 819 C allele was also associated with IM in HP+ individuals (OR = 2.32, 95%CI: 1.21-4.43, P = 0.011), while the PTPN11 A allele was associated with IM in HP- individuals (OR = 2.51, 95%CI: 1.16-5.40, P = 0.019), but showed an inverse association in HP+ subjects (OR = 0.46, 95%CI: 0.21-0.99, P = 0.048).
Polymorphisms in NQO1, IL-10 and PTPN11, in combination with HP status, could be used to identify individuals who are more likely to develop IM and therefore GC.
肠化生（IM）是胃癌（GC）发生发展过程中的一种重要前驱病变。本研究旨在调查先前与GC风险相关的遗传因素与IM的可能关联。在一个患GC风险较高的新加坡华裔人群中，对14个候选基因中的18个多态性进行了评估。
通过单因素和多因素分析，比较了有IM（n = 128）和无IM（n = 246）个体的基因型频率。
NQO1 609 T等位基因携带者在幽门螺杆菌血清阳性（HP+）个体中与IM相关（OR = 2.61，95%CI：1.18 - 5.80，P = 0.018）。IL-10 819 C等位基因在HP+个体中也与IM相关（OR = 2.32，95%CI：1.21 - 4.43，P = 0.011），而PTPN11 A等位基因在HP-个体中与IM相关（OR = 2.51，95%CI：1.16 - 5.40，P = 0.019），但在HP+个体中呈负相关（OR = 0.46，95%CI：0.21 - 0.99，P = 0.048）。
NQO1、IL-10和PTPN11的多态性，结合HP状态，可用于识别更易发生IM进而患GC的个体。
