水合氯醛麻醉可拮抗3,4-亚甲基二氧甲基苯丙胺的神经毒性。

Chloral hydrate anesthesia antagonizes the neurotoxicity of 3,4-methylenedioxymethamphetamine.

作者信息

Schmidt C J, Black C K, Abbate G M, Taylor V L

机构信息

Merrell Dow Research Institute, Cincinnati, OH 45215.

出版信息

Eur J Pharmacol. 1990 Nov 27;191(2):213-6. doi: 10.1016/0014-2999(90)94149-r.

DOI:10.1016/0014-2999(90)94149-r

Abstract

We report that maintaining rats under chloral hydrate anesthesia for the first 3 h following the administration of 3,4-methylenedioxymethamphetamine (MDMA) blocks the decrease in forebrain concentrations of 5-hydroxytryptamine (5-HT) measured 1 week later. In contrast, the acute effect of MDMA (3 h) on forebrain 5-HT was not altered by the anesthetic. This protective effect of chloral hydrate was not due to an anesthetic-induced hypothermia but may be related to the hypothesized role of dopamine in the neurotoxic effects of MDMA.

摘要

我们报告称，在给予3,4-亚甲基二氧甲基苯丙胺（摇头丸）后的最初3小时内，将大鼠置于水合氯醛麻醉状态下，可阻止1周后测得的前脑5-羟色胺（5-羟色胺）浓度的降低。相比之下，水合氯醛并未改变摇头丸（3小时）对前脑5-羟色胺的急性作用。水合氯醛的这种保护作用并非由于麻醉引起的体温过低，而是可能与多巴胺在摇头丸神经毒性作用中的假定作用有关。

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