Shi W S, Bunney B S
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510.
Neuropharmacology. 1990 Nov;29(11):1095-7. doi: 10.1016/0028-3908(90)90119-c.
The effects of intracerebroventricular (i.c.v.) administration of NT on the activity of midbrain DA neurons were studied in rats using single unit recording techniques. NT (i.c.v., 50 micrograms) was found to have no significant effect on the spontaneous activity of DA cells. On the other hand, NT treatment significantly attenuated the inhibitory effect of quinpirole (i.v.), a specific D2 agonist, on a subpopulation of DA cells. This result is consistent with previous behavioral and biochemical studies suggesting that NT may produce some of its effects through modulation of central DA systems.
采用单单位记录技术，在大鼠中研究了脑室内（i.c.v.）注射神经降压素（NT）对中脑多巴胺（DA）神经元活性的影响。发现NT（脑室内注射，50微克）对DA细胞的自发活性无显著影响。另一方面，NT处理显著减弱了特异性D2激动剂喹吡罗（静脉注射）对一部分DA细胞的抑制作用。这一结果与先前的行为学和生物化学研究一致，提示NT可能通过调节中枢DA系统产生其部分作用。
