Kurz Max J, Hou Jyhgong Gabriel
Munroe-Meyer Institute for Genetics and Rehabilitation, Physical Therapy Department, University of Nebraska Medical Center, 985450 Nebraska Medical Center, Omaha, NE 68198-5450, USA.
J Comput Neurosci. 2010 Feb;28(1):131-6. doi: 10.1007/s10827-009-0192-0. Epub 2009 Oct 13.
The aim of the investigation was to explore the influence of levodopa therapy on the regularity of the structural variations present in the lower extremity joints of individuals with Parkinson's disease (PD). Ten participants with PD walked on a treadmill during the states of "off" and "on" levodopa. Approximate entropy was used to quantify the regularity of the structural variations present in the joint kinematics. Additionally, a pseudo-periodic surrogation analysis was used to evaluate if changes in the regularity of the joint's movement were associated with a noisy or deterministic motor process. This investigation provided two key findings. The first was that the structural variations present in ankle joint were more regular with levodopa therapy. The second was that changes in the structural variations were related to a deterministic motor process. This indicated that the variations present in the walking patterns of individuals with PD most likely arose from higher-order neural couplings rather than noise in the motor process. Monitoring the regularity of the structural variations present in gait may help improve the management of PD.
该研究的目的是探讨左旋多巴治疗对帕金森病（PD）患者下肢关节结构变化规律的影响。10名PD患者在左旋多巴“关”和“开”的状态下在跑步机上行走。近似熵用于量化关节运动学中结构变化的规律。此外，使用伪周期替代分析来评估关节运动规律的变化是否与噪声或确定性运动过程相关。这项研究有两个关键发现。第一个是左旋多巴治疗后踝关节的结构变化更有规律。第二个是结构变化与确定性运动过程有关。这表明PD患者行走模式中的变化很可能源于高阶神经耦合，而不是运动过程中的噪声。监测步态中结构变化的规律可能有助于改善PD的管理。
