School of Engineering, University of British Columbia Okanagan, Kelowna, BC, Canada V1V 1V7.
Biomed Microdevices. 2010 Feb;12(1):115-24. doi: 10.1007/s10544-009-9366-9.
Research on so called digital microfluidic systems (DMS) capable of manipulating individual microdroplets on a cell-based structure has enormously increased in the past few years, mainly due to the demand of the technology-dependent biomedical applications. Significant research in this area has been related to the simulation and modeling of droplet motion, demonstration of different drop actuation techniques on laboratory-scale prototypes, and droplet routing and scheduling for more efficient assay procedures. This paper introduces the basics of the control analysis and design of a DMS, which is a relatively unexplored area in digital microfluidics. This paper starts with a discussion on a simplified dynamic model of droplet motion in a planar array of cells, and continues with more complicated dynamic models that are necessary to realize the structure of an appropriate closed-loop control system for the DMS. The control analysis and design includes both the transient and steady-state responses of the DMS under external driving forces. The proposed control analysis and design approach is implemented into SIMULINK models to demonstrate the performance of the DMS through simulation using the system parameters previously reported in the literature.
近年来，在基于细胞结构上能够操作单个微滴的所谓数字微流控系统（DMS）的研究方面取得了巨大进展，这主要是由于对技术依赖型生物医学应用的需求。该领域的重要研究涉及液滴运动的模拟和建模、在实验室规模原型上演示不同的液滴致动技术，以及为更有效的分析程序进行液滴路由和调度。本文介绍了 DMS 的控制分析和设计的基础知识，这是数字微流控中一个相对未被探索的领域。本文首先讨论了在细胞平面阵列中液滴运动的简化动力学模型，然后继续讨论更复杂的动力学模型，这些模型对于为 DMS 实现适当的闭环控制系统结构是必要的。控制分析和设计包括在外部驱动力下 DMS 的瞬态和稳态响应。所提出的控制分析和设计方法被实现到 SIMULINK 模型中，通过使用文献中先前报道的系统参数进行仿真来演示 DMS 的性能。
