Sobczak Magdalena, Majewski Łukasz, Redowicz Maria Jolanta
Pracownia Molekularnych Podstaw Ruchów Komórkowych, Zakład Biochemii, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Warszawa.
Postepy Biochem. 2009;55(2):239-46.
Myosins, actin-dependent molecular motors are expressed in almost all eukaryotic cells where are engaged in a panoply of cellular processes such as muscle contraction, cell migration and adhesion, intracellular trafficking, cytokinesis, endocytosis and secretion. In recent years a number of reports has been published revealing nuclear localization of myosins as well as actin and actin-binding proteins. Namely, nuclear form of myosin IC (NMI), myosin VI, myosin XVIB and myosin XVIIIB were found in nucleus. NMI and myosin VI seem to be involved in gene transcription and possibly intranuclear transport. In this paper, current knowledge on the role of myosin motors in nucleus has been presented.
肌球蛋白是肌动蛋白依赖性分子马达，几乎在所有真核细胞中都有表达，参与一系列细胞过程，如肌肉收缩、细胞迁移与黏附、细胞内运输、胞质分裂、胞吞作用和分泌。近年来，已有多篇报道揭示了肌球蛋白以及肌动蛋白和肌动蛋白结合蛋白的核定位。具体而言，在细胞核中发现了肌球蛋白IC（NMI）、肌球蛋白VI、肌球蛋白XVIB和肌球蛋白XVIIIB的核形式。NMI和肌球蛋白VI似乎参与基因转录以及可能的核内运输。本文介绍了关于肌球蛋白马达在细胞核中作用的当前知识。
