Moore J B
Res Commun Chem Pathol Pharmacol. 1977 Aug;17(4):639-47.
The effects of adrenergic and cholinergic agents as well as the effects of disodium cromoglycate (DSCG) on the levels of cyclic AMP and cyclic GMP in mouse lung fragments were studied. Levels of cyclic AMP were enhanced by two of the known beta-adrenergic agonists, epinephrine and isoproterenol. This increase was abolished by propanolol, a recognized beta-adrenergic antagonist. Disodium cromoglycate, a proposed inhibitor of phosphodiesterases, alone caused a slight, significant increase in cyclic AMP. However, in the presence of epinephrine, levels of cyclic AMP were potentiated by DSCG. DSCG behaves, therefore, as a typical cyclic AMP phosphodiesterase inhibitor. Cyclic GMP levels were increased by carbachol, acetylcholine, and the phosphodiesterase inhibitor, aminophylline, but not by DSCG, or beta-adrenergic agonists.
研究了肾上腺素能和胆碱能药物以及色甘酸钠（DSCG）对小鼠肺组织中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）水平的影响。两种已知的β-肾上腺素能激动剂肾上腺素和异丙肾上腺素可提高cAMP水平。这种增加被公认的β-肾上腺素能拮抗剂普萘洛尔消除。色甘酸钠是一种推测的磷酸二酯酶抑制剂，单独使用时可使cAMP略有显著增加。然而，在肾上腺素存在的情况下，DSCG可增强cAMP水平。因此，DSCG表现为典型的cAMP磷酸二酯酶抑制剂。卡巴胆碱、乙酰胆碱和磷酸二酯酶抑制剂氨茶碱可提高cGMP水平，但DSCG或β-肾上腺素能激动剂不能。
