内皮依赖性β1肾上腺素能作用引起的血管平滑肌舒张。

Vascular smooth muscle relaxation by endothelium-dependent beta 1-adrenergic action.

Aikawa J, Akatsuka N

Third Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990;97(2):311-5. doi: 10.1016/0742-8413(90)90147-2.

Abstract

Norepinephrine (NE) (10(-5) M) in rabbit aorta relaxed ring segments with endothelium precontracted with 10(-6) M NE, but not segments without endothelium. 2. The relaxation was inhibited with metoprolol and methylene blue, but not inhibited with yohimbine and indomethacin. 3. NE (10(-5) M) significantly elevated tissue c-GMP levels in segments with endothelium. 4. These studies suggest that the vascular relaxation by high doses of NE is mediated by the release of endothelium-derived relaxing factor (EDRF) induced by the stimulation of beta 1-adrenoceptor.

摘要

去甲肾上腺素（NE）（10⁻⁵ M）可使预先用10⁻⁶ M NE预收缩的兔主动脉带内皮环段舒张，但对无内皮环段无此作用。2. 美托洛尔和亚甲蓝可抑制这种舒张，但育亨宾和吲哚美辛不能抑制。3. NE（10⁻⁵ M）可使带内皮环段的组织c - GMP水平显著升高。4. 这些研究表明，高剂量NE引起的血管舒张是由β1 - 肾上腺素受体刺激诱导释放的内皮源性舒张因子（EDRF）介导的。