De Serio A, Carratù M R, Mitolo-Chieppa D, Serio M
Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università di Bari.
Boll Soc Ital Biol Sper. 1990 Oct;66(10):937-45.
The evidence that ATP is released with noradrenaline as a cotransmitter from sympathetic nerve endings in the isolated guinea-pig vas deferens, had led to investigate the potential interactive effects of P2 and alpha 1 receptors, extending the observations to potentially synergistic interactions of histamine-, acetylcholine- and serotonin-receptors. Ineffective concentrations of histamine, carbachol and serotonin increase the neurogenic response to field stimulation; this effect is prevented by the specific antagonist. The responses to the exogenously applied ATP and noradrenaline are increased as well, suggesting that this synergistic interaction of carbachol is less specific. It can be envisaged that receptor complex is a multicomponent system with subunits specific for the primary neurotransmitter and accessory subunits which may interact to increase the responsiveness of the target cell to simultaneous afferent stimuli.
有证据表明，在分离的豚鼠输精管中，ATP作为共递质与去甲肾上腺素一起从交感神经末梢释放，这促使人们研究P2和α1受体的潜在相互作用，并将观察结果扩展到组胺、乙酰胆碱和5-羟色胺受体的潜在协同相互作用。无效浓度的组胺、卡巴胆碱和5-羟色胺可增加对场刺激的神经源性反应；这种效应可被特异性拮抗剂阻断。对外源性应用的ATP和去甲肾上腺素的反应也会增加，这表明卡巴胆碱的这种协同相互作用特异性较低。可以设想，受体复合物是一个多组分系统，具有对主要神经递质特异的亚基和辅助亚基，它们可能相互作用以增加靶细胞对同时传入刺激的反应性。
