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胰岛移植的漫漫征途。

The long road to pancreatic islet transplantation.

机构信息

Department of Surgery, Columbia University College of Physicians and Surgeons, 177 Fort Washington Ave., Milstein Pavilion, 7 SK, New York, NY, 10032, USA.

出版信息

World J Surg. 2010 Apr;34(4):625-7. doi: 10.1007/s00268-009-0246-5.

DOI:10.1007/s00268-009-0246-5
PMID:19830482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3097058/
Abstract

Some of us (MAH) have known Dr. Eric Rose when he was a resident, a fellow in cardiothoracic surgery, the director of heart transplantation program, the director of Cardiothoracic Division, and finally as Valentine and Johnson and Johnson Professor and Chairman of Department of Surgery at Columbia University for the last 15 years. Having this long relationship with Dr. Rose, I was not sure where or how to begin this tribute to my former resident, colleague, collaborator, and eventually director. It was as an innovative and courageous Chairman that Dr. Rose had a major impact on me when he appointed me as a Residency Program Director and through his remarkable interest and support of educational changes led to a rebirth and growth of the surgical residency at Columbia NY Presbyterian Hospital to one of the leading programs in the country. But the greatest inspiration that Dr. Rose brought to the Department of Surgery was his fearless and relentless support of ventures into the unknown. When faced with heart transplantation as a junior faculty member, he went on to lay the foundation for the largest heart transplant program in the world; when challenged by development and lack of acceptance of Left Ventricular Assist Devices, he guided their approval following appropriate multiinstitutional studies which led to their adoption as standard of care. His influence extended to the support of a Pancreatic Islet Transplantation Program, originally inspired by his predecessor and mentor, Dr. Keith Reemtsma. Doctor Rose invested and encouraged both the clinical and experimental development of this program under my guidance as part of his dedication to innovation.

摘要

我们中的一些人(MAH)在 Eric Rose 医生还是住院医师、心胸外科研究员、心脏移植项目主任、心胸外科主任,最后在过去的 15 年里担任哥伦比亚大学 Valentine 和 Johnson 和 Johnson 教授和外科系主任时就认识他了。我与 Rose 医生有着长期的关系,因此不确定从哪里开始或如何开始对我的前住院医师、同事、合作者,最终的主任进行赞扬。正是作为一位创新和勇敢的主席,Rose 医生任命我为住院医师项目主任,并通过他对教育变革的显著兴趣和支持,对我产生了重大影响,使哥伦比亚长老会医院的外科住院医师培训计划得以重生和发展,成为全国领先的项目之一。但 Rose 医生为外科系带来的最大启发是他对未知领域的无畏和不懈支持。当他作为一名初级教员面临心脏移植时,他为世界上最大的心脏移植项目奠定了基础;当他面临左心室辅助装置的发展和缺乏接受时,他指导了适当的多机构研究,使其获得批准,并将其作为标准治疗方法。他的影响力还扩展到支持胰岛移植项目,该项目最初是由他的前任和导师 Keith Reemtsma 博士启发的。Rose 医生在我的指导下,投资并鼓励该项目的临床和实验发展,这是他对创新的奉献精神的一部分。

相似文献

1
The long road to pancreatic islet transplantation.胰岛移植的漫漫征途。
World J Surg. 2010 Apr;34(4):625-7. doi: 10.1007/s00268-009-0246-5.
2
Pancreatic islet transplantation in diabetes.糖尿病中的胰岛移植
Int J Artif Organs. 1991 Feb;14(2):74-7.
3
Twenty years of clinical islet transplantation at the Diabetes Research Institute--University of Miami.迈阿密大学糖尿病研究所20年临床胰岛移植历程。
Clin Transpl. 2004:177-204.
4
Transplantation of pancreatic islet tissue and the control of diabetes mellitus.胰岛组织移植与糖尿病的控制
Invest Cell Pathol. 1978 Jan-Mar;1(1):65-97.
5
Evolution of Islet Transplantation for the Last 30 Years.过去30年胰岛移植的发展历程。
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Prospects for pancreatic islet transplantation.胰岛移植的前景。
World J Surg. 1986 Jun;10(3):410-21. doi: 10.1007/BF01655301.
7
[Pancreatic islet transplantation in the therapy of diabetic diseases].
Nihon Rinsho. 1990 Dec;48 Suppl:1052-8.
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Bone marrow-derived mesenchymal stem cells improve islet graft function in diabetic rats.骨髓间充质干细胞改善糖尿病大鼠胰岛移植功能。
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Mesenchymal stem cells and islet cotransplantation in diabetic rats: improved islet graft revascularization and function by human adipose tissue-derived stem cells preconditioned with natural molecules.间质干细胞与胰岛共移植于糖尿病大鼠:经天然分子预处理的人脂肪组织来源干细胞改善胰岛移植物再血管化和功能。
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Contrib Nephrol. 1989;73:217-26; discussion 226-8. doi: 10.1016/0011-2240(88)90393-8.

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Rev Diabet Stud. 2014 Spring;11(1):84-101. doi: 10.1900/RDS.2014.11.84. Epub 2014 May 10.
2
Proangiogenic hydrogels within macroporous scaffolds enhance islet engraftment in an extrahepatic site.在大孔支架内的促血管生成水凝胶增强了肝外部位胰岛的植入。
Tissue Eng Part A. 2013 Dec;19(23-24):2544-52. doi: 10.1089/ten.TEA.2012.0686. Epub 2013 Aug 9.

本文引用的文献

1
Human pancreatic islets and diabetes research.人类胰岛与糖尿病研究。
JAMA. 2009 Apr 15;301(15):1580-7. doi: 10.1001/jama.2009.482.
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11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.11C-二氢丁苯那嗪PET对长期1型糖尿病患者和健康对照者胰腺的研究
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CTLA4-Ig-modified dendritic cells inhibit lymphocyte-mediated alloimmune responses and prolong the islet graft survival in mice.
CTLA4免疫球蛋白修饰的树突状细胞抑制淋巴细胞介导的同种免疫反应并延长小鼠胰岛移植的存活时间。
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Integrin signaling via RGD peptides and anti-beta1 antibodies confers resistance to apoptosis in islets of Langerhans.通过RGD肽和抗β1抗体的整合素信号传导赋予胰岛对细胞凋亡的抗性。
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Vascular endothelial growth factor-releasing scaffolds enhance vascularization and engraftment of hepatocytes transplanted on liver lobes.释放血管内皮生长因子的支架可增强移植到肝叶上的肝细胞的血管化和植入。
Tissue Eng. 2005 May-Jun;11(5-6):715-22. doi: 10.1089/ten.2005.11.715.
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Five-year follow-up after clinical islet transplantation.临床胰岛移植后的五年随访。
Diabetes. 2005 Jul;54(7):2060-9. doi: 10.2337/diabetes.54.7.2060.
9
Identification of tissue-restricted transcripts in human islets.人类胰岛中组织特异性转录本的鉴定。
Endocrinology. 2004 Oct;145(10):4513-21. doi: 10.1210/en.2004-0691. Epub 2004 Jul 1.
10
CD4+CD25+ regulatory T cells mediate acquired transplant tolerance.CD4+CD25+调节性T细胞介导获得性移植耐受。
Transpl Immunol. 2003 Jul-Sep;11(3-4):287-93. doi: 10.1016/S0966-3274(03)00046-7.