三联苯衍生的 N(H)-桥联氮杂杯芳烃：在固态中对小分子中性分子的包合作用、合成、结构。

Triptycene-derived N(H)-bridged azacalixarenes: synthesis, structure, and encapsulation of small neutral molecules in the solid state.

机构信息

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Org Lett. 2009 Nov 19;11(22):5294-7. doi: 10.1021/ol902246c.

DOI:10.1021/ol902246c

PMID:19831391

Abstract

Four pairs of novel N(H)-bridged azacalixarenes derived from triptycene were synthesized by both one-pot and two-step fragment-coupling approaches. Due to the unique 3D rigid structure of triptycene, the macrocycles all adopted fixed conformations in both solution and solid state. X-ray crystallographic analyses also revealed that the cis isomers with boat conformations showed the capability of encapsulating methanol and acetone molecules inside.

摘要

四种新型 N(H)-桥联氮杂杯芳烃衍生物是通过一锅法和两步分段偶联法合成的。由于三并苯独特的 3D 刚性结构，大环在溶液和固态中均采用固定构象。X 射线晶体学分析还表明，具有船式构象的顺式异构体具有包合甲醇和丙酮分子的能力。