成人幼年特发性关节炎相关性葡萄膜炎：病例系列研究。
Juvenile idiopathic arthritis associated uveitis in adults: a case series.
机构信息
The Alfred Hospital, Melbourne, VIC, Australia.
出版信息
Ocul Immunol Inflamm. 2009 Sep-Oct;17(5):330-4. doi: 10.3109/09273940903118626.
PURPOSE
To report a series of adults with uveitis following juvenile idiopathic arthritis (JIA) and uveitis as children.
METHODS
The clinical features, treatment, complications, and visual outcome were ascertained for 17 patients at a single centre.
RESULTS
Seventeen adults with previously diagnosed JIA and ongoing uveitis (30 eyes) were identified. All required at least topical steroids. The complication rate was high (15 patients, 23 eyes), most frequently cataract (57%), glaucoma (33%), and posterior synechiae (30%). The rate of visual acuity loss to 6/12 threshold (6/12 or worse) for patients with uveitis < 15 years (Group A) was 13.3%, (and 6.7% to 6/60 threshold) and for patients with uveitis >15 years (Group B) was 26.7% (and 20% to 6/60 threshold). Overall, the rate of visual acuity loss to 6/12 threshold was 20% (6 eyes) and to 6/60 threshold, 13.3% (4 eyes).
CONCLUSIONS
JIA may be associated with ongoing uveitis and complications in adulthood.
目的
报告一组儿童期患有幼年特发性关节炎（JIA）和葡萄膜炎、成年后患葡萄膜炎的患者。
方法
在一个中心确定了 17 名患有先前诊断的 JIA 和持续葡萄膜炎（30 只眼）的成年患者的临床特征、治疗、并发症和视力结果。
结果
确定了 17 名先前诊断为 JIA 且持续患有葡萄膜炎（30 只眼）的成年患者。所有患者均至少需要局部类固醇治疗。并发症发生率高（15 名患者，23 只眼），最常见的是白内障（57%）、青光眼（33%）和后粘连（30%）。葡萄膜炎<15 年（A 组）的患者视力丧失至 6/12 阈值（6/12 或更差）的比例为 13.3%（6/60 阈值为 6.7%），葡萄膜炎>15 年（B 组）的患者视力丧失至 6/12 阈值的比例为 26.7%（6/60 阈值为 20%）。总体而言，视力丧失至 6/12 阈值的比例为 20%（6 只眼），至 6/60 阈值的比例为 13.3%（4 只眼）。
结论
JIA 可能与成年后持续存在的葡萄膜炎和并发症有关。
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