Roikhel V M, Fokina G I, Khokhlov A I, Sobolev S G, Zavalishin I A, Korolev M B, Pogodina V V
Institute of Poliomyelitis and Viral Encephalitis USSR AMS, Moscow.
Acta Virol. 1990 Dec;34(6):545-53.
We followed the dynamics of arginase activity, the ultrastructural changes, and accumulation of the scrapie agent in the CNS of scrapie-infected mice. The arginase activity has been shown to increase 5-fold within the first 3-4 months of the incubation period followed by subsequent fall at its end. The peak of increased arginase activity coincided with appearance of multilayer membranes, whereas the decrease of this activity was associated with the greatest development of status spongiosus, synaptic degeneration, accumulation of five-layer membranes as well as with maximal accumulation of the scrapie agent in the CNS. Examination of 100 patients with different forms of amyotrophic lateral sclerosis (ALS) revealed a 2-8-fold increase of arginase levels in the cerebrospinal fluid (CSF) as compared with the background levels in the comparative groups of control patients. Similar enzyme alterations in scrapie--and in ALS--are discussed in terms of possible resemblance of their pathogenesis.
我们追踪了感染羊瘙痒病小鼠中枢神经系统中精氨酸酶活性的动态变化、超微结构改变以及羊瘙痒病病原体的蓄积情况。研究表明，在潜伏期的最初3至4个月内，精氨酸酶活性增加了5倍，随后在潜伏期结束时下降。精氨酸酶活性增加的峰值与多层膜的出现同时发生，而该活性的降低则与海绵状状态的最大发展、突触变性、五层膜的蓄积以及中枢神经系统中羊瘙痒病病原体的最大蓄积相关。对100例不同形式肌萎缩侧索硬化症（ALS）患者的检查显示，与对照组患者的背景水平相比，脑脊液（CSF）中精氨酸酶水平升高了2至8倍。本文根据羊瘙痒病和ALS发病机制可能存在的相似性，对二者中类似的酶变化进行了讨论。
