Schmalbach Barbara, Lang Nicolas
Neurology, Christian-Albrechts-University Kiel, and Department of Neurology, University Hospital Schleswig-Holstein, Kiel, Schleswig Holstein 24105, Germany.
Discov Med. 2009 Oct;8(42):130-2.
Rasmussen encephalitis (RE) is characterized by chronic inflammation of one cerebral hemisphere which causes intractable epileptic seizures and progressive neurological deficits. Since antiepileptic pharmacotherapy is often ineffective the traditional therapy for Rasmussen encephalitis is hemispherectomy in one of its modern variants which renders the patient seizure free but leads to a severe deficit. To escape this dilemma, immunomodulatory therapeutic approaches such as rituximab, a monoclonal anti-CD20 antibody, offer an alternative and bear promising therapeutic potentials in Rasmussen encephalitis.
拉斯姆森脑炎（RE）的特征是一侧大脑半球的慢性炎症，可导致顽固性癫痫发作和进行性神经功能缺损。由于抗癫痫药物治疗往往无效，拉斯姆森脑炎的传统治疗方法是采用现代变体之一的大脑半球切除术，这可使患者不再发作，但会导致严重的功能缺损。为摆脱这一困境，免疫调节治疗方法，如单克隆抗CD20抗体利妥昔单抗，提供了一种替代方案，并在拉斯姆森脑炎中具有有前景的治疗潜力。
