自身反应性T细胞的抗原特异性是其进入胰岛的关键吗？
Is antigen specificity of autoreactive T cells the key to islet entry?
作者信息
Penaranda Cristina, Bluestone Jeffrey A
机构信息
Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.
出版信息
Immunity. 2009 Oct 16;31(4):534-6. doi: 10.1016/j.immuni.2009.09.006.
PMID:19833083
Abstract
It has been widely hypothesized that pancreatic islet infiltrates include both islet-antigen-specific and nonspecific T cells. In this issue of Immunity, Lennon et al. (2009) demonstrate that islet-antigen specificity is required for accumulation in the islets.
摘要
人们普遍推测，胰岛浸润细胞包括胰岛抗原特异性和非特异性T细胞。在本期《免疫》杂志中，列侬等人（2009年）证明，胰岛抗原特异性是在胰岛中积累所必需的。
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