Department of Psychology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78705, USA.
Physiol Behav. 2010 Jan 12;99(1):8-16. doi: 10.1016/j.physbeh.2009.10.001.
With salivary assessment of steroid hormones increasing, more work is needed to address fundamental properties of steroid hormone levels in humans. Using a test-retest design and radioimmunoassay assessment of salivary steroids, we tested the reliability of testosterone, cortisol, and progesterone levels across two weeks, as well as the effects of oral contraceptives, menstrual cycle phase, and time of day on steroid hormone levels. Testosterone and cortisol were found to be highly reliable in both sexes. Progesterone was found to be reliable after collapsing across sex. Oral contraceptive use was associated with lower levels of testosterone, but did not affect cortisol. Contrary to expectations, oral contraceptives also did not affect progesterone. Menstrual cycle was found to affect levels of progesterone, but not testosterone or cortisol. Time of day had an effect on cortisol, on progesterone only at one testing time, and no effect on testosterone. We explored the interhormone correlations among testosterone, progesterone, and cortisol. All three hormones were positively correlated with one another in men. In women, progesterone was positively correlated with testosterone and cortisol, but testosterone and cortisol were uncorrelated.
随着对类固醇激素唾液评估的增加，需要更多的工作来解决人类类固醇激素水平的基本特性。我们使用测试-再测试设计和放射免疫测定评估唾液类固醇，测试了睾酮、皮质醇和孕酮水平在两周内的可靠性，以及口服避孕药、月经周期阶段和一天中的时间对类固醇激素水平的影响。在两性中，睾酮和皮质醇的可靠性都很高。孕酮在跨性别后被发现是可靠的。口服避孕药的使用与睾酮水平降低有关，但不影响皮质醇。与预期相反，口服避孕药也不影响孕酮。月经周期被发现会影响孕酮水平，但不会影响睾酮或皮质醇。一天中的时间对皮质醇有影响，仅在一次测试时间对孕酮有影响，对睾酮没有影响。我们探讨了睾酮、孕酮和皮质醇之间的激素间相关性。在男性中，所有三种激素彼此之间呈正相关。在女性中，孕酮与睾酮和皮质醇呈正相关，但睾酮和皮质醇之间没有相关性。
