Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
G Ital Dermatol Venereol. 2009 Oct;144(5):583-93.
A complex array of reparative tissue mechanisms occur in the skin after epithelial barrier disruption and many patients develop abnormal healing responses that result in inadequate restoration of the cutaneous surface. Consequently, this may manifest in various maladies such as ulceration if re-epithelialization fails to occur or a hypertrophic scar or keloid if the wound healing process becomes too exuberant. Cutaneous injuries that result in scar tissue formation or ulceration are relatively common and lead patients to seek treatment for cosmetic or functional improvement. Laser technology has evolved over the past few decades to become the treatment of choice for many types of scars. Animal models and in vitro studies have also shown lasers to facilitate more rapid resolution of cutaneous ulceration, although this has yet to be consistently observed in humans. The evidence that addresses the use of lasers for scars and chronic wounds will be reviewed herein.
在表皮屏障破坏后，皮肤中会发生一系列复杂的修复组织机制，许多患者会出现异常的愈合反应，导致皮肤表面无法充分恢复。因此，如果不能重新上皮化，可能会出现溃疡等各种疾病，如果愈合过程过于活跃，则会出现增生性瘢痕或瘢痕疙瘩。导致瘢痕组织形成或溃疡的皮肤损伤较为常见，导致患者寻求治疗以改善外观或功能。过去几十年中，激光技术不断发展，成为许多类型瘢痕的治疗选择。动物模型和体外研究也表明，激光可以促进皮肤溃疡更快地愈合，但这在人类中尚未得到一致观察。本文将回顾用于治疗瘢痕和慢性伤口的激光的相关证据。
