Coiras Mayte, López-Huertas María Rosa, Pérez-Olmeda Mayte, Alcamí José
AIDS Immunopathology Unit, National Centre of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.
Nat Rev Microbiol. 2009 Nov;7(11):798-812. doi: 10.1038/nrmicro2223.
HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.
HIV-1 能够感染活化的和静止的、非分裂细胞，之后病毒基因组可永久整合到宿主细胞染色体中。潜伏性HIV-1储存库在初次感染早期就已建立，即使在高效抗逆转录病毒治疗的情况下，它也是根除病毒的主要障碍。本综述分析了HIV-1潜伏建立所必需的分子机制及其与不同细胞和解剖学储存库的关系，并讨论了针对储存库中病毒持续性的当前治疗策略、其主要局限性和未来前景。
