Wendt P
Institut für Experimentelle Chirurgie der TU München.
Langenbecks Arch Chir Suppl II Verh Dtsch Ges Chir. 1990:1047-50.
Surgical threads of a variety of resorbable suture materials (Cat plain and Chrom Cat, Serag Wiessner, Polyglactin 910 and Polydioxanon, Ethicon and polyglycolic acid, Dexon) were incubated up to 7 days at 37 degrees C in Varidase-containing media (Lederle Cyanamid, 1000 IU/ml in 0.9% NaCl or citrated human plasma). Thereafter the knot-breaking strength remained within 90.0 and 108.2% of the respective control threads (incubation in Varidase-free media, n = 7, n.s.). The dose-dependent lysis of fibrin glue by Varidase is effectively inhibited by small amounts of aprotinin (15 KIU/ml as compared with 1000-3000 KIU/ml in routine application). The inhibitor is bound to the matrix and not readily eluted.
将多种可吸收缝合材料制成的手术缝线（普通羊肠线和铬制羊肠线、Serag Wiessner、聚乙醇酸910和聚二氧杂环己酮、Ethicon和聚乙醇酸、Dexon）在含链激酶的培养基（Lederle Cyanamid，在0.9%氯化钠或枸橼酸化人血浆中为1000 IU/ml）中于37℃孵育长达7天。此后，打结断裂强度保持在各自对照缝线（在无链激酶的培养基中孵育，n = 7，无显著性差异）的90.0%至108.2%范围内。少量抑肽酶（15 KIU/ml，而常规应用中为1000 - 3000 KIU/ml）可有效抑制链激酶对纤维蛋白胶的剂量依赖性溶解。该抑制剂与基质结合，不易洗脱。
