Reichel Valeska, Baehr Carsten, Fricker Gert
Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls University, Heidelberg, Germany.
ALTEX. 2007;24 Spec No:53-5.
The choroid plexus represents the second barrier between blood and brain besides the blood brain barrier. The barrier function is set up by plexus epithelial cells, which are equipped with a variety of active transport systems. However in contrast to the epithelial organs location and extent of expression of these transporters may be different. Studying the choroid plexus (CP) epithelium in living animals is difficult due to its complex morphology, anatomical location and small size. Therefore, an in vitro monolayer model of choroid plexus was established from porcine brain in order to study the functional contribution of transport proteins to drug transport across CP tissue with special focus on ABC-proteins.
脉络丛是除血脑屏障外血液与大脑之间的第二道屏障。屏障功能由丛上皮细胞建立，这些细胞配备了多种主动转运系统。然而，与上皮器官相比，这些转运蛋白的表达位置和范围可能有所不同。由于脉络丛（CP）上皮的形态复杂、解剖位置特殊且体积较小，在活体动物中研究它具有一定难度。因此，为了研究转运蛋白对药物跨CP组织转运的功能贡献，特别是关注ABC蛋白，我们从猪脑中建立了脉络丛的体外单层模型。
