Department of Gastroenterology, Hospital Universitario de la Princesa, Madrid, Spain.
Health Qual Life Outcomes. 2009 Oct 16;7:90. doi: 10.1186/1477-7525-7-90.
The RANGE (Retrospective ANalysis of GastroEsophageal reflux disease [GERD]) study assessed differences among patients consulting a primary care physician due to GERD-related reasons in terms of: symptoms, diagnosis and management, response to treatment, and effects on productivity, costs and health-related quality of life. This subanalysis of RANGE determined the impact of GERD on productivity in work and daily life.
RANGE was conducted at 134 primary care sites across six European countries (Germany, Greece, Norway, Spain, Sweden and the UK). All subjects (aged >or=18 years) who consulted with their primary care physician over a 4-month identification period were screened retrospectively, and those consulting at least once for GERD-related reasons were identified (index visit). From this population, a random sample was selected to enter the study and attended a follow-up appointment, during which the impact of GERD on productivity while working (absenteeism and presenteeism) and in daily life was evaluated using the self-reported Work Productivity and Activity Impairment Questionnaire for patients with GERD (WPAI-GERD).
Overall, 373,610 subjects consulted with their primary care physician over the 4-month identification period, 12,815 for GERD-related reasons (3.4%); 2678 randomly selected patients attended the follow-up appointment. Average absenteeism due to GERD was highest in Germany (3.2 hours/week) and lowest in the UK (0.4 hours/week), with an average of up to 6.7 additional hours/week lost due to presenteeism in Norway. The average monetary impact of GERD-related work absenteeism and presenteeism were substantial in all countries (from euro55/week per employed patient in the UK to euro273/patient in Sweden). Reductions in productivity in daily life of up to 26% were observed across the European countries.
GERD places a significant burden on primary care patients, in terms of work absenteeism and presenteeism and in daily life. The resulting costs to the local economy may be substantial. Improved management of GERD could be expected to lessen the impact of GERD on productivity and reduce costs.
RANGE（胃食管反流病[GERD]回顾性分析）研究评估了因 GERD 相关原因就诊于初级保健医生的患者之间的差异：症状、诊断和管理、治疗反应以及对生产力、成本和健康相关生活质量的影响。RANGE 的这项亚分析确定了 GERD 对工作和日常生活生产力的影响。
RANGE 在六个欧洲国家（德国、希腊、挪威、西班牙、瑞典和英国）的 134 个初级保健场所进行。在为期 4 个月的识别期内，所有年龄大于或等于 18 岁的患者均进行回顾性筛查，并确定至少因 GERD 相关原因就诊一次的患者（就诊）。从该人群中随机抽取样本进入研究并参加随访预约，在此期间使用胃食管反流病患者工作生产力和活动障碍问卷（WPAI-GERD）评估 GERD 对工作时（旷工和出勤）和日常生活中的生产力的影响。
总体而言，在为期 4 个月的识别期内，共有 373610 名患者就诊于初级保健医生，其中 12815 名因 GERD 相关原因就诊（3.4%）；随机选择了 2678 名患者参加随访预约。由于 GERD 导致的平均旷工时间在德国最高（3.2 小时/周），在英国最低（0.4 小时/周），在挪威由于出勤导致的旷工时间每周最多增加 6.7 小时。在所有国家，因 GERD 相关工作旷工和出勤导致的生产力损失的平均货币影响都相当大（从英国每名就业患者每周 55 欧元到瑞典每名患者每周 273 欧元）。在整个欧洲国家，日常生活生产力的下降高达 26%。
GERD 对初级保健患者的工作旷工和出勤以及日常生活造成了重大负担。对当地经济造成的损失可能相当大。预计 GERD 管理的改善将减轻 GERD 对生产力的影响并降低成本。
