不安分的大脑：注意力缺陷多动障碍、静息态功能连接和个体内变异性。
The restless brain: attention-deficit hyperactivity disorder, resting-state functional connectivity, and intrasubject variability.
机构信息
Neidich Professor of Child and Adolescent Psychiatry, Phyllis Green and Randolph Côwen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, New York, USA.
出版信息
Can J Psychiatry. 2009 Oct;54(10):665-72. doi: 10.1177/070674370905401003.
Abstract
OBJECTIVES
To highlight recent advances in the conceptualization of attention-deficit hyperactivity disorder (ADHD) emerging from neuroimaging and endophenotypic approaches.
METHODS
We selectively reviewed recent published literature on the phenomena of resting-state functional connectivity, intrasubject variability, and diffusion tensor imaging pertaining to ADHD.
RESULTS
Recent advances based on the novel approach of resting-state functional connectivity appear to be highly promising and likely to link to studies of intrasubject variability.
CONCLUSIONS
Endophenotypic fractionation may offer a means of addressing the complex heterogeneity of ADHD on the path to testable models of pathophysiology. Such models focusing on intrasubject variability, intrinsic brain activity, and reward-related processing are progressing rapidly.
摘要
目的
突出神经影像学和内表型方法在注意力缺陷多动障碍（ADHD）概念化方面的最新进展。
方法
我们选择性地回顾了有关 ADHD 的静息态功能连接、个体内变异性和弥散张量成像现象的最新发表的文献。
结果
基于静息态功能连接的新方法的最新进展似乎很有希望，并可能与个体内变异性的研究联系起来。
结论
内表型分离可能为 ADHD 的复杂异质性提供一种途径，以建立可测试的病理生理学模型。这种关注个体内变异性、内在大脑活动和与奖励相关的处理的模型正在迅速发展。
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