Hale T Sigi, Bookheimer Susan, McGough James J, Phillips Joseph M, McCracken James T
Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
J Atten Disord. 2007 Sep;11(2):125-40. doi: 10.1177/1087054706294101. Epub 2007 May 9.
Executive dysfunction in ADHD is well supported. However, recent studies suggest that more fundamental impairments may be contributing. We assessed brain function in adults with ADHD during simple and complex forms of processing.
We used functional magnetic resonance imaging with forward and backward digit spans to investigate number repetitions and complex working memory function. If pathology is limited to higher cognitive operations, group differences should be confined to the backward condition.
During the forward digit span, ADHD participants exhibited greater activation of LH linguistic processing areas and increased activation of right frontal and parietal cortices. During the backward digit span, they exhibited greater activation of LH linguistic processing areas and failed to activate bilateral parietal regions important for the complex executive operations.
Abnormal brain function among adult ADHD participants was not limited to complex executive functions. Abnormal processing of numeric stimuli was indicated during both simple and complex cognitive operations.
注意缺陷多动障碍（ADHD）中的执行功能障碍有充分的证据支持。然而，最近的研究表明可能存在更根本的损伤因素。我们评估了患有ADHD的成年人在简单和复杂加工形式下的脑功能。
我们使用功能磁共振成像结合顺背和倒背数字广度任务来研究数字复述和复杂工作记忆功能。如果病变仅限于高级认知操作，那么组间差异应该仅限于倒背条件下。
在顺背数字广度任务中，ADHD参与者左侧半球（LH）语言加工区域激活增强，右侧额叶和顶叶皮质激活增加。在倒背数字广度任务中，他们左侧半球语言加工区域激活增强，并且未能激活对复杂执行操作很重要的双侧顶叶区域。
成年ADHD参与者的脑功能异常并不局限于复杂的执行功能。在简单和复杂认知操作过程中均显示出对数字刺激的异常加工。
