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基孔肯雅病毒在病毒诱导性关节炎中的核心地位：发病机制的可能细胞和分子机制。

Chikungunya virus takes centre stage in virally induced arthritis: possible cellular and molecular mechanisms to pathogenesis.

机构信息

Infection Research Grouping, University of la Réunion, St Denis, Ile de la Réunion.

出版信息

Microbes Infect. 2009 Dec;11(14-15):1206-18. doi: 10.1016/j.micinf.2009.10.001. Epub 2009 Oct 14.

DOI:10.1016/j.micinf.2009.10.001
PMID:19835977
Abstract

Chikungunya virus (CHIKV) causes an acute symptomatic illness with fever, skin rash (hypersensitivity vasculitis), incapacitating arthralgia which can evolve to chronic arthritis in elderly patients. Clinical observations from cohort studies have been corroborated with data from experimental infection in several mouse and non-human primate models as discussed herein.

摘要

基孔肯雅病毒（CHIKV）可引起伴有发热、皮疹（超敏性血管炎）的急性症状性疾病，并导致老年患者发生致残性关节炎，进而可能发展为慢性关节炎。本文讨论了从多个小鼠和非人灵长类动物模型的实验感染中获得的数据，这些数据与队列研究中的临床观察结果相吻合。

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