ECNIS Unit, University of Mainz, D-55131 Mainz, Germany.
Mutat Res. 2009 Nov-Dec;680(1-2):83-6. doi: 10.1016/j.mrgentox.2009.10.006. Epub 2009 Oct 15.
Circadian rhythm is an integral and not replaceable part of the organism's homeostasis. Its signalling is multidimensional, overlooking global networks such as chromatin remodelling, cell cycle, DNA damage and repair as well as nuclear receptors function. Understanding its global networking will allow us to follow up not only organism dysfunction and pathology (including chemical carcinogenesis) but well-being in general having in mind that time is not always on our side.
昼夜节律是机体内稳态的一个不可或缺且不可替代的组成部分。它的信号传递是多维的，不仅涉及染色质重塑、细胞周期、DNA 损伤和修复以及核受体功能等全局网络，还包括这些网络。了解其全局网络将使我们不仅能够跟踪观察机体功能障碍和病理学（包括化学致癌作用），还能够跟踪观察整体健康状况，因为我们要记住，时间并不总是站在我们这边。
