苯并噻唑类 Rho 相关激酶（ROCK-II）抑制剂。
Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors.
机构信息
Translational Research Institute and Department of Molecular Therapeutics, The Scripps Research Institute, Florida, 130 Scripps Way #2A1, Jupiter, FL 33458, United States.
出版信息
Bioorg Med Chem Lett. 2009 Dec 1;19(23):6686-90. doi: 10.1016/j.bmcl.2009.09.115. Epub 2009 Oct 3.
PMID:19837589
Abstract
A series of benzothiazole derivatives as ROCK inhibitors have been discovered. Compounds with good biochemical and cellular potency, and sufficient kinase selectivity have been identified.
摘要
已经发现了一系列苯并噻唑衍生物作为 ROCK 抑制剂。已经鉴定出具有良好生化和细胞效力以及足够激酶选择性的化合物。
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