Shiroma Takuya, Yamaguchi Misako, Nagai Atsushi
Dept. of Respiratory Medicine, Tachikawa General Hospital.
Gan To Kagaku Ryoho. 2009 Oct;36(10):1729-31.
In December 2006, a 55-year-old-man was given a diagnosis of adenocarcinoma of the lung with multiple brain metastases. Systemic chemotherapy was given consisting of carboplatin plus paclitaxel and carboplatin plus gemcitabine. But with the increase of the brain metastases, he was admitted in February 2008. He received whole brain radiation therapy and was given erlotinib at the same time. The brain metastases disappeared and primary lung tumor decreased after the start of therapy. No side effect was observed. Although further investigations are needed to completely determine the efficacy of this treatment procedure, it seems clear that combining erlotinib with radiation therapy produces a synergy effect on the cancer.
2006年12月,一名55岁男性被诊断为肺癌伴多发脑转移。给予了由卡铂加紫杉醇以及卡铂加吉西他滨组成的全身化疗。但随着脑转移灶增多,他于2008年2月入院。他接受了全脑放射治疗,同时给予厄洛替尼。治疗开始后,脑转移灶消失,原发性肺肿瘤缩小。未观察到副作用。尽管需要进一步研究以完全确定该治疗方案的疗效,但似乎很明显,厄洛替尼与放射治疗联合对癌症产生了协同效应。