Lekx Katie S, deKemp Robert A, Beanlands Rob S B, Wisenberg Gerald, Wells Glenn, Stodilka Robert Z, Lortie Mireille, Klein Ran, Zabel Pamela, Kovacs Michael S, Sykes Jane, Prato Frank S
Lawson Health Research Institute and Nuclear Medicine Department, St. Joseph's Health Care, London, Canada.
Nucl Med Commun. 2010 Jan;31(1):75-81. doi: 10.1097/MNM.0b013e328332b359.
Previous studies have shown the ability of rubidium-82 ((82)Rb) positron emission tomography (PET) imaging to quantitatively measure myocardial blood flow (MBF), many of which are performed using two-dimensional (2D) imaging. Three-dimensional (3D) imaging provides increased sensitivity and may result in decreased costs owing to a reduction in the required injected activity of radiotracer. This study compares 2D and 3D (82)Rb PET MBF results obtained in the same imaging session.
Three-dimensional and 2D (82)Rb perfusion imaging was performed in canines on a GE Discovery LS PET/CT scanner at rest and during hyperemia in stunned and infarcted tissue. MBF (ml/min/g) was determined using a 1-compartment model and an extraction correction of the uptake rate and analyzed using a standard 17-segment model.
A strong, significant correlation was present (rho = 0.95, P<0.0001). Average 3D MBF values were slightly lower at rest and higher during stress versus 2D. MBF results in normal, stunned, and infarcted tissue differed by 7% on average and significant increases in MBF from rest to hyperemia were noted with both the techniques.
These results imply that MBF results obtained in 3D are comparable with traditional 2D imaging. Therefore, it may be possible to use 3D imaging with lower administered activity, helping to reduce costs and patient dose without compromising quantitative information.
既往研究已表明，82铷（82Rb）正电子发射断层扫描（PET）成像能够定量测量心肌血流量（MBF），其中许多研究采用二维（2D）成像。三维（3D）成像提高了灵敏度，并且由于放射性示踪剂所需注射活度的降低，可能会降低成本。本研究比较了在同一次成像检查中获得的2D和3D 82Rb PET的MBF结果。
在GE Discovery LS PET/CT扫描仪上，对犬在静息状态以及在顿抑和梗死组织充血期间进行三维和二维82Rb灌注成像。使用单室模型并对摄取率进行提取校正来确定MBF（毫升/分钟/克），并使用标准的17节段模型进行分析。
存在强且显著的相关性（rho = 0.95，P<0.0001）。与2D相比，静息时平均3D MBF值略低，应激时略高。正常、顿抑和梗死组织的MBF结果平均相差7%，两种技术均显示从静息到充血时MBF有显著增加。
这些结果表明，3D获得的MBF结果与传统2D成像相当。因此，有可能使用较低给药活度的3D成像，有助于在不影响定量信息的情况下降低成本和患者剂量。
