Manabe Osamu, Yoshinaga Keiichiro, Katoh Chietsugu, Naya Masanao, deKemp Robert A, Tamaki Nagara
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
J Nucl Med. 2009 Jan;50(1):68-71. doi: 10.2967/jnumed.108.055673. Epub 2008 Dec 17.
The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aim of this study was to investigate the short-term repeatability of such measurements.
Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart.
There was no significant difference in repeated rest MBF (0.77+/-0.25 vs. 0.82+/-0.25 mL/min/g, P=0.31; mean difference, 6.18%+/-12.22%) or repeated hyperemic MBF (3.35+/-1.37 vs. 3.39+/-1.37 mL/min/g, P=0.81; mean difference, 1.17%+/-13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia.
MBF using 82Rb is highly reproducible using a same-day short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.
尚未评估使用82Rb正电子发射断层扫描（PET）测量静息和充血状态下心肌血流量（MBF）的可重复性。本研究的目的是调查此类测量的短期可重复性。
15名健康志愿者接受了静息和药物负荷82Rb PET检查，两次检查间隔60分钟。
重复测量的静息MBF（0.77±0.25对0.82±0.25 mL/分钟/克，P = 0.31；平均差异，6.18%±12.22%）或重复测量的充血MBF（3.35±1.37对3.39±1.37 mL/分钟/克，P = 0.81；平均差异，1.17%±13.64%）无显著差异。静息MBF的可重复性系数为0.19 mL/分钟/克，充血状态下为0.92 mL/分钟/克。
使用82Rb测量MBF在同一天短期重复测量方案下具有高度可重复性。使用82Rb PET进行系列MBF测量应能够量化治疗干预对MBF的急性影响。
