Hillert J, Osterman P O, Olerup O
Center for BioTechnology, Karolinska Institute, Novum, Huddinge, Sweden.
J Neuroimmunol. 1991 Jan;31(1):67-72. doi: 10.1016/0165-5728(91)90088-o.
The distribution of HLA class II alleles in Guillain-Barré syndrome (GBS) has previously been reported only for HLA-DR. We report here the results of genomic typing for HLA-DR, -DQ and -DP allelic variability by restriction fragment length polymorphism analysis in 49 patients with a history of GBS. No association was found to HLA-DR, -DQ or -DP alleles or HLA-DR-DQ haplotypes. Subgrouping of patients according to severity of disease, as measured by disability or muscular weakness, or response to plasmapheresis treatment, also failed to reveal significant associations. These data suggest that HLA class II genes do not confer susceptibility to GBS.
此前关于吉兰-巴雷综合征（GBS）中HLA-II类等位基因的分布仅报道了HLA-DR。我们在此报告了对49例有GBS病史患者进行限制性片段长度多态性分析，以检测HLA-DR、-DQ和-DP等位基因变异性的基因分型结果。未发现与HLA-DR、-DQ或-DP等位基因或HLA-DR-DQ单倍型存在关联。根据残疾或肌肉无力衡量的疾病严重程度或对血浆置换治疗的反应对患者进行亚组分析，也未发现显著关联。这些数据表明，HLA-II类基因不会使个体易患GBS。
