Li Yang-Qiu, Zhou Yu-Bing, Yang Li-Jian
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Oct;17(5):1127-9.
PPP2R5C is one of the members of regulatory subunits of protein phosphatase 2A (PP2A), which plays a critical role in cell proliferation, differentiation and transformation, based on its induction of dephosphorylation of P53 at various residues. Recently, it was characterized that the alteration of expression pattern of PPP2R5C is associated with cell malignant transformation, thus PPP2R5C was thought as a marker for progressive disease in B-CLL. In this article the gene structure and biological function of PPP2R5C as well as relation of PPP2R5C with genesis and development of cancer were discussed.
PPP2R5C是蛋白磷酸酶2A（PP2A）调节亚基的成员之一，它通过诱导P53在多个位点的去磷酸化，在细胞增殖、分化和转化中发挥关键作用。最近有研究表明，PPP2R5C表达模式的改变与细胞恶性转化有关，因此PPP2R5C被认为是B细胞慢性淋巴细胞白血病（B-CLL）进展性疾病的一个标志物。本文讨论了PPP2R5C的基因结构、生物学功能以及PPP2R5C与癌症发生发展的关系。
